[HTML][HTML] Snail-family proteins: role in carcinogenesis and prospects for antitumor therapy
MA Yastrebova, AI Khamidullina, VV Tatarskiy… - Acta …, 2021 - ncbi.nlm.nih.gov
Acta Naturae, 2021•ncbi.nlm.nih.gov
The review analyzes Snail family proteins, which are transcription factors involved in the
regulation of the epithelial-mesenchymal transition (EMT) of tumor cells. We describe the
structure of these proteins, their post-translational modification, and the mechanisms of Snail-
dependent regulation of genes. The role of Snail proteins in carcinogenesis, invasion, and
metastasis is analyzed. Furthermore, we focus on EMT signaling mechanisms involving
Snail proteins. Next, we dissect Snail signaling in hypoxia, a condition that complicates …
regulation of the epithelial-mesenchymal transition (EMT) of tumor cells. We describe the
structure of these proteins, their post-translational modification, and the mechanisms of Snail-
dependent regulation of genes. The role of Snail proteins in carcinogenesis, invasion, and
metastasis is analyzed. Furthermore, we focus on EMT signaling mechanisms involving
Snail proteins. Next, we dissect Snail signaling in hypoxia, a condition that complicates …
Abstract
The review analyzes Snail family proteins, which are transcription factors involved in the regulation of the epithelial-mesenchymal transition (EMT) of tumor cells. We describe the structure of these proteins, their post-translational modification, and the mechanisms of Snail-dependent regulation of genes. The role of Snail proteins in carcinogenesis, invasion, and metastasis is analyzed. Furthermore, we focus on EMT signaling mechanisms involving Snail proteins. Next, we dissect Snail signaling in hypoxia, a condition that complicates anticancer treatment. Finally, we offer classes of chemical compounds capable of down-regulating the transcriptional activity of Snails. Given the important role of Snail proteins in cancer biology and the potential for pharmacological inhibition, Snail family proteins may be considered promising as therapeutic targets.
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