Solution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain α-keto acid dehydrogenase complex
CF Chang, HT Chou, JL Chuang, DT Chuang… - Journal of Biological …, 2002 - ASBMB
The lipoyl-bearing domain (LBD) of the transacylase (E2) subunit of the branched-chain α-
keto acid dehydrogenase complex plays a central role in substrate channeling in this
mitochondrial multienzyme complex. We have employed multidimensional heteronuclear
NMR techniques to determine the structure and dynamics of the LBD of the human branched-
chain α-keto acid dehydrogenase complex (hbLBD). Similar to LBD from other members of
the α-keto acid dehydrogenase family, the solution structure of hbLBD is a flattened β-barrel …
keto acid dehydrogenase complex plays a central role in substrate channeling in this
mitochondrial multienzyme complex. We have employed multidimensional heteronuclear
NMR techniques to determine the structure and dynamics of the LBD of the human branched-
chain α-keto acid dehydrogenase complex (hbLBD). Similar to LBD from other members of
the α-keto acid dehydrogenase family, the solution structure of hbLBD is a flattened β-barrel …
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