In this study, some of the physical properties of the Karacadag stone from Diyarbakir, Sanliurfa stone from Sanliurfa, Mardin and Midyat stones from Mardin and Hasankeyf stone from Batman which have been used extensively as a building material in Southeastern Anatolia Region were investigated. The stones having different features have been used as building materials in every places all over the region for ages. Heat and mechanical properties of these stones have not been searched yet. The aim of this work is to find out how suitable these rocks are as structural materials. For this aim, two specimens from different sources for each stone chosen from various places in Southeastern Anatolia Region, have been taken. After chemical analysis, the experiments for determining the heat conductivity and heat capacity, water absorption and mechanical strength were carried out. The results are compared with the other building materials especially in the aspects of energy saving, strength and natural comfort conditions.