Major depressive disorder (MDD), one of the most frequently encountered forms of mental
illness and a leading cause of disability worldwide, poses a major challenge to genetic
analysis. To date, no robustly replicated genetic loci have been identified, despite analysis
of more than 9,000 cases. Here, using low-coverage whole-genome sequencing of 5,303
Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and
5,337 controls screened to exclude MDD, we identified, and subsequently replicated in an …

Sparse whole-genome sequencing identifies two loci for major depressive disorder (vol 523,
pg 588, 2015) - University of Surrey …