[HTML][HTML] Spatial covariance analysis reveals the residue-by-residue thermodynamic contribution of variation to the CFTR fold
F Anglès, C Wang, WE Balch - Communications Biology, 2022 - nature.com
Although the impact of genome variation on the thermodynamic properties of function on the
protein fold has been studied in vitro, it remains a challenge to assign these relationships
across the entire polypeptide sequence in vivo. Using the Gaussian process regression
based principle of Spatial CoVariance, we globally assign on a residue-by-residue basis the
biological thermodynamic properties that contribute to the functional fold of CFTR in the cell.
We demonstrate the existence of a thermodynamically sensitive region of the CFTR fold …
protein fold has been studied in vitro, it remains a challenge to assign these relationships
across the entire polypeptide sequence in vivo. Using the Gaussian process regression
based principle of Spatial CoVariance, we globally assign on a residue-by-residue basis the
biological thermodynamic properties that contribute to the functional fold of CFTR in the cell.
We demonstrate the existence of a thermodynamically sensitive region of the CFTR fold …
Spatial covariance analysis reveals the residue-by-residue thermodynamic contribution of variation to the CFTR fold
A Frédéric, C Wang, WE Balch - Communications Biology, 2022 - search.proquest.com
Although the impact of genome variation on the thermodynamic properties of function on the
protein fold has been studied in vitro, it remains a challenge to assign these relationships
across the entire polypeptide sequence in vivo. Using the Gaussian process regression
based principle of Spatial CoVariance, we globally assign on a residue-by-residue basis the
biological thermodynamic properties that contribute to the functional fold of CFTR in the cell.
We demonstrate the existence of a thermodynamically sensitive region of the CFTR fold …
protein fold has been studied in vitro, it remains a challenge to assign these relationships
across the entire polypeptide sequence in vivo. Using the Gaussian process regression
based principle of Spatial CoVariance, we globally assign on a residue-by-residue basis the
biological thermodynamic properties that contribute to the functional fold of CFTR in the cell.
We demonstrate the existence of a thermodynamically sensitive region of the CFTR fold …
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