Background Optimal drug treatment for patients with resistant hypertension is undefined. We
aimed to test the hypotheses that resistant hypertension is most often caused by excessive
sodium retention, and that spironolactone would therefore be superior to non-diuretic add-
on drugs at lowering blood pressure. Methods In this double-blind, placebo-controlled,
crossover trial, we enrolled patients aged 18–79 years with seated clinic systolic blood
pressure 140 mm Hg or greater (or≥ 135 mm Hg for patients with diabetes) and home …

[Spironolactone versus placebo, bisoprolol and doxazosin to determine the optimal
treatment for drug-resistant hypertension]. - Abstract - Europe PMC … [Spironolactone
versus placebo, bisoprolol and doxazosin to determine the optimal treatment for drug-resistant
hypertension]. … This is a comment on "Spironolactone versus placebo, bisoprolol, and
doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2):
a randomised, double-blind, crossover trial." Lancet. 2015 Nov 21;386(10008):2059-68. …