The general view of cancer progression is based on a gradual evolutionary process,
involving a continuous acquisition of genetic changes in individual cells with successive
subclonal selection and expansion. 1 However, whole-genome sequencing (WGS) in
cancer has led to discover the chromothripsis phenomenon, in which focal regions of the
genome undergo extensive chromosome fragmentation and reorganization causing
structural genomic complexity in some tumor cells. 2 Chromothripsis was first described in a …

Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by
longitudinal genomic analysis - PMC … Sporadic and reversible chromothripsis in chronic
lymphocytic leukemia revealed by longitudinal genomic analysis … Articles from Leukemia
are provided here courtesy of Nature Publishing Group …