[HTML][HTML] Standardization of extracellular vesicle measurements by flow cytometry through vesicle diameter approximation
E van der Pol, A Sturk, T van Leeuwen… - Journal of thrombosis …, 2018 - Elsevier
Essentials• Platelet extracellular vesicles (EVs) concentrations measured by flow cytometers
are incomparable.• A model is applied to convert ambiguous scatter units to EV diameter in
nanometer.• Most included flow cytometers lack the sensitivity to detect EVs of 600 nm and
smaller.• The model outperforms polystyrene beads for comparability of platelet EV
concentrations. Summary: Background Detection of extracellular vesicles (EVs) by flow
cytometry has poor interlaboratory comparability, owing to differences in flow cytometer …
are incomparable.• A model is applied to convert ambiguous scatter units to EV diameter in
nanometer.• Most included flow cytometers lack the sensitivity to detect EVs of 600 nm and
smaller.• The model outperforms polystyrene beads for comparability of platelet EV
concentrations. Summary: Background Detection of extracellular vesicles (EVs) by flow
cytometry has poor interlaboratory comparability, owing to differences in flow cytometer …
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