The progress of modern market economies is largely determined by its ability to encourage and develop Entrepreneurship, and to create an appropriate entrepreneurial environment. New innovative companies, in the form of startups, are emerging as the most important factors in this process. Their formation is often determined by the startup skills, that are crucial element of entrepreneurial behavior and attitudes. In terms of business, which is accompanied by rapid changes and uncertainties, the consideration of this issue is essential. Successful entrepreneurial venture requires some startup skills, which every entrepreneur should have. Adequate understanding and acceptance of changes, as well as the advantages and risks they bring with them, have a huge influence on the development of Entrepreneurship and innovation as the main drivers of the business progress of every company, and also on economic growth and strengthening the competitiveness of each country.