Lipids have fundamental roles in the structure, energetics, and signaling of cells and
organisms. The recent discovery of fatty acid esters of hydroxy fatty acids (FAHFAs), lipids
with potent antidiabetic and anti-inflammatory activities, indicates that our understanding of
the composition of lipidome and the function of lipids is incomplete. The ability to synthesize
and test FAHFAs was critical in elucidating the roles of these lipids, but these studies were
performed with racemic mixtures, and the role of stereochemistry remains unexplored. Here …