Abstract Purpose of Review: Death from stroke has decreased over the past decade, with
stroke now the fifth leading cause of death in the United States. In addition, the incidence of
new and recurrent stroke is declining, likely because of the increased use of specific
prevention medications, such as statins and antihypertensives. Despite these positive trends
in incidence and mortality, many strokes remain preventable. The major modifiable risk
factors are hypertension, diabetes mellitus, tobacco smoking, and hyperlipidemia, as well as …

Overall, secondary stroke prevention includes a multifactorial approach. This article
incorporates evidence from guidelines and published studies and uses an illustrative case
study throughout the article to provide examples of secondary prevention management of
stroke risk factors.