Structural analysis of the glycosylated intact HIV-1 gp120–b12 antibody complex using hydroxyl radical protein footprinting
Glycoprotein gp120 is a surface antigen and virulence factor of human immunodeficiency
virus 1. Broadly neutralizing antibodies (bNAbs) that react to gp120 from a variety of HIV
isolates offer hope for the development of broadly effective immunogens for vaccination
purposes, if the interactions between gp120 and bNAbs can be understood. From a
structural perspective, gp120 is a particularly difficult system because of its size, the
presence of multiple flexible regions, and the large amount of glycosylation, all of which are …
virus 1. Broadly neutralizing antibodies (bNAbs) that react to gp120 from a variety of HIV
isolates offer hope for the development of broadly effective immunogens for vaccination
purposes, if the interactions between gp120 and bNAbs can be understood. From a
structural perspective, gp120 is a particularly difficult system because of its size, the
presence of multiple flexible regions, and the large amount of glycosylation, all of which are …
[引用][C] Structural Analysis of the Glycosylated Intact HIV-1 gp120–b12 Antibody Complex Using Hydroxyl Radical Protein Footprinting
L Xiaoyan, I Keigo, W Aaron, W Shixia, Z Peng… - 2017
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