The interaction of brain lipids with α-synuclein may play an important role in the
pathogenesis of Parkinson disease (PD). Docosahexaenoic acid (DHA) is an abundant fatty
acid of neuronal membranes, and it is presents at high levels in brain areas with α-synuclein
inclusions of patients with PD. In animal models, an increase of DHA content in the brain
induces α-synuclein oligomer formation in vivo. However, it is not clear whether these
oligomeric species are the precursors of the larger aggregates found in Lewy bodies of post …