Structural basis for accommodation of emerging B. 1.351 and B. 1.1. 7 variants by two potent SARS-CoV-2 neutralizing antibodies
… present in B.1.351 and B.1.1.7 strains, we determined their cryoelectron microscopy (cryo-EM)
structures in complex with spike. We used the 52 currently known complex structures of …
structures in complex with spike. We used the 52 currently known complex structures of …
[PDF][PDF] Structural Basis for Accommodation of Emerging B. 1.351 and B. 1.1. 7 Variants by Two Potent SARS-CoV-2 Neutralizing Antibodies
… mutations present in B.1.351 and B.1.1.7 strains, we determined their cryo-EM …
Structural basis of antibody 2-7 accommodation of mutation N501Y in emerging strains. …
Structural basis of antibody 2-7 accommodation of mutation N501Y in emerging strains. …
[HTML][HTML] Antibody resistance of SARS-CoV-2 variants B. 1.351 and B. 1.1. 7
… -CoV-2 virus that emerged in 2019. The recent detection of SARS-CoV-2 variants B.1.1.7 in
the UK 11 and B.1.351 in … More importantly, B.1.351 is resistant to a major group of potent …
the UK 11 and B.1.351 in … More importantly, B.1.351 is resistant to a major group of potent …
LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants
…, I Hughes, L Munoz, HC Palma, B Ramamurthy… - Cell reports, 2022 - cell.com
… B cell screening pipeline, we isolated LY-CoV1404 (bebtelovimab), a highly potent SARS-CoV-2 …
-CoV1404 potently neutralizes variants, including B.1.1.7, B.1.351, B.1.617.2, B.1.427/…
-CoV1404 potently neutralizes variants, including B.1.1.7, B.1.351, B.1.617.2, B.1.427/…
Broadly-neutralizing antibodies against emerging SARS-CoV-2 variants
… in the variant viruses B.1.1.7, B.1.351, and P.1, while the added substitution at 417 in P.1 and
B.1.351 … the preserved neutralizing potency against B.1.1.7, P1, B.1.351 and B.1.429 (22). …
B.1.351 … the preserved neutralizing potency against B.1.1.7, P1, B.1.351 and B.1.429 (22). …
[HTML][HTML] Broadly neutralizing antibodies against COVID-19
… broad potency against previously and currently circulating variants. … variants and, ideally,
new variants that will emerge in the future. … Genetic and structural basis for SARS-CoV-2 variant …
new variants that will emerge in the future. … Genetic and structural basis for SARS-CoV-2 variant …
[HTML][HTML] Impact of new variants on SARS-CoV-2 infectivity and neutralization: A molecular assessment of the alterations in the spike-host protein interactions
… of variants highlight how full-atomic structure and dynamics analyses are required for assessing
the response to newly emerging variants. … and structural basis for SARS-CoV-2 variant …
the response to newly emerging variants. … and structural basis for SARS-CoV-2 variant …
A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope
… Structural analysis showed that SARS2-38 engaged a conserved epitope proximal to the …
may limit the loss of potency of therapies or vaccines against emerging SARS-CoV-2 variants. …
may limit the loss of potency of therapies or vaccines against emerging SARS-CoV-2 variants. …
Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants
… Recent emerging viral variants have raised concern because … of B.1.351 and P.1 lineages
are mapped onto a structure of … could largely restore the neutralization potency of other IGHV3-…
are mapped onto a structure of … could largely restore the neutralization potency of other IGHV3-…
Structural evaluation of the spike glycoprotein variants on SARS-CoV-2 transmission and immune evasion
… the new E484K mutation may have on the B.1.1.7 variant. … potency of two potent RBD-directed
antibodies, 1-57 and 2-7… against both the B.1.351 and B.1.1.7 variants, although a 9.5-fold …
antibodies, 1-57 and 2-7… against both the B.1.351 and B.1.1.7 variants, although a 9.5-fold …