Structural basis for accommodation of emerging B. 1.351 and B. 1.1. 7 variants by two potent SARS-CoV-2 neutralizing antibodies

G Cerutti, M Rapp, Y Guo, F Bahna, J Bimela… - Structure, 2021 - cell.com
… present in B.1.351 and B.1.1.7 strains, we determined their cryoelectron microscopy (cryo-EM)
structures in complex with spike. We used the 52 currently known complex structures of …

[PDF][PDF] Structural Basis for Accommodation of Emerging B. 1.351 and B. 1.1. 7 Variants by Two Potent SARS-CoV-2 Neutralizing Antibodies

ER Reddem, J Yu, P Wang, L Liu, Y Huang, DD Ho… - researchgate.net
… mutations present in B.1.351 and B.1.1.7 strains, we determined their cryo-EM …
Structural basis of antibody 2-7 accommodation of mutation N501Y in emerging strains. …

[HTML][HTML] Antibody resistance of SARS-CoV-2 variants B. 1.351 and B. 1.1. 7

…, L Liu, S Iketani, Y Luo, Y Guo, M Wang, J Yu, B Zhang… - Nature, 2021 - nature.com
… -CoV-2 virus that emerged in 2019. The recent detection of SARS-CoV-2 variants B.1.1.7 in
the UK 11 and B.1.351 in … More importantly, B.1.351 is resistant to a major group of potent

LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

…, I Hughes, L Munoz, HC Palma, B Ramamurthy… - Cell reports, 2022 - cell.com
B cell screening pipeline, we isolated LY-CoV1404 (bebtelovimab), a highly potent SARS-CoV-2
-CoV1404 potently neutralizes variants, including B.1.1.7, B.1.351, B.1.617.2, B.1.427/…

Broadly-neutralizing antibodies against emerging SARS-CoV-2 variants

LB Shrestha, N Tedla, RA Bull - Frontiers in immunology, 2021 - frontiersin.org
… in the variant viruses B.1.1.7, B.1.351, and P.1, while the added substitution at 417 in P.1 and
B.1.351 … the preserved neutralizing potency against B.1.1.7, P1, B.1.351 and B.1.429 (22). …

[HTML][HTML] Broadly neutralizing antibodies against COVID-19

D Zhou, J Ren, EE Fry, DI Stuart - Current Opinion in Virology, 2023 - Elsevier
… broad potency against previously and currently circulating variants. … variants and, ideally,
new variants that will emerge in the future. … Genetic and structural basis for SARS-CoV-2 variant

[HTML][HTML] Impact of new variants on SARS-CoV-2 infectivity and neutralization: A molecular assessment of the alterations in the spike-host protein interactions

MH Cheng, JM Krieger, A Banerjee, Y Xiang, B Kaynak… - Iscience, 2022 - cell.com
… of variants highlight how full-atomic structure and dynamics analyses are required for assessing
the response to newly emerging variants. … and structural basis for SARS-CoV-2 variant

A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope

LA VanBlargan, LJ Adams, Z Liu, RE Chen, P Gilchuk… - Immunity, 2021 - cell.com
Structural analysis showed that SARS2-38 engaged a conserved epitope proximal to the …
may limit the loss of potency of therapies or vaccines against emerging SARS-CoV-2 variants. …

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

M Yuan, D Huang, CCD Lee, NC Wu, AM Jackson… - Science, 2021 - science.org
… Recent emerging viral variants have raised concern because … of B.1.351 and P.1 lineages
are mapped onto a structure of … could largely restore the neutralization potency of other IGHV3-…

Structural evaluation of the spike glycoprotein variants on SARS-CoV-2 transmission and immune evasion

MZ Salleh, JP Derrick, ZZ Deris - International journal of molecular …, 2021 - mdpi.com
… the new E484K mutation may have on the B.1.1.7 variant. … potency of two potent RBD-directed
antibodies, 1-57 and 2-7… against both the B.1.351 and B.1.1.7 variants, although a 9.5-fold …