Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody
F Lennartz, F Brod, R Dabbs, K Miura… - Nature …, 2018 - nature.com
The quest to develop an effective malaria vaccine remains a major priority in the fight
against global infectious disease. An approach with great potential is a transmission-
blocking vaccine which induces antibodies that prevent establishment of a productive
infection in mosquitos that feed on infected humans, thereby stopping the transmission
cycle. One of the most promising targets for such a vaccine is the gamete surface protein,
Pfs48/45. Here we establish a system for production of full-length Pfs48/45 and use this to …
against global infectious disease. An approach with great potential is a transmission-
blocking vaccine which induces antibodies that prevent establishment of a productive
infection in mosquitos that feed on infected humans, thereby stopping the transmission
cycle. One of the most promising targets for such a vaccine is the gamete surface protein,
Pfs48/45. Here we establish a system for production of full-length Pfs48/45 and use this to …
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