Diesel exhaust is the major source of ultrafine particles released during traffic-related
pollution. Subjects with chronic respiratory diseases are at greater risk for exacerbations
during exposure to air pollution. This study evaluated the effects of subchronic exposure to a
low-dose of diesel exhaust particles (DEP). Sixty male BALB/c mice were divided into two
groups:(a) Saline: nasal instillation of saline (n= 30); and (b) DEP: nasal instillation of 30 µg
of DEP/10 µl of saline (n= 30). Nasal instillations were performed 5 days a week, over 30 …

ReP USP - Detalhe do registro: Subchronic effects of nasally instilled diesel exhaust
particulates on the nasal and airway epithelia in mice …