Recently, very high resolution (VHR) panchromatic and multispectral (MS) remote-sensing images can be acquired easily. However, it is still a challenging task to fuse and classify these VHR images. Generally, there are two ways for the fusion and classification of panchromatic and MS images. One way is to use a panchromatic image to sharpen an MS image, and then classify a pan-sharpened MS image. Another way is to extract features from panchromatic and MS images, respectively, and then combine these features for classification. In this paper, we propose a superpixel-based multiple local convolution neural network (SML-CNN) model for panchromatic and MS images classification. In order to reduce the amount of input data for the CNN, we extend simple linear iterative clustering algorithm for segmenting MS images and generating superpixels. Superpixels are taken as the basic analysis unit instead of pixels. To make full advantage of the spatial-spectral and environment information of superpixels, a superpixel-based multiple local regions joint representation method is proposed. Then, an SML-CNN model is established to extract an efficient joint feature representation. A softmax layer is used to classify these features learned by multiple local CNN into different categories. Finally, in order to eliminate the adverse effects on the classification results within and between superpixels, we propose a multi-information modification strategy that combines the detailed information and semantic information to improve the classification performance. Experiments on the classification of Vancouver and Xi’an panchromatic and MS image data sets have demonstrated the effectiveness of the proposed approach.