[HTML][HTML] Sustained Hypoxic Pulmonary Vasoconstriction in the Isolated Perfused Rat Lung: Effect of α1-adrenergic Receptor Agonist

F Ketabchi, Z Karimi, SMS Moosavi - Iranian Journal of Medical …, 2014 - ncbi.nlm.nih.gov
Background: Alveolar hypoxia induces monophasic pulmonary vasoconstriction in vivo,
biphasic vasoconstriction in the isolated pulmonary artery, and controversial responses in
the isolated perfused lung. Pulmonary vascular responses to sustained alveolar hypoxia
have not been addressed in the isolated perfused rat lung. In this study, we investigated the
effect of sustained hypoxic ventilation on pulmonary artery pressure in the present of
phenylephrine, an α 1-receptor agonist, under the above condition. Methods: We performed …

Sustained hypoxic pulmonary vasoconstriction in the isolated perfused rat lung: effect of alpha [1]-adrenergic receptor agonist

K Farzaneh, K Zinab, M Seyed Mostafa S - 2014 - pesquisa.bvsalud.org
Background: Alveolar hypoxia induces monophasic pulmonary vasoconstriction in vivo,
biphasic vasoconstriction in the isolated pulmonary artery, and controversial responses in
the isolated perfused lung. Pulmonary vascular responses to sustained alveolar hypoxia
have not been addressed in the isolated perfused rat lung. In this study, we investigated the
effect of sustained hypoxic ventilation on pulmonary artery pressure in the present of
phenylephrine, an alpha [1]-receptor agonist, under the above condition
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