Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells
A Mansouri, LD Ridgway, AL Korapati, Q Zhang… - Journal of Biological …, 2003 - ASBMB
The efficacy of cisplatin in cancer chemotherapy is limited by the development of resistance.
Although the molecular mechanisms involved in chemoresistance are poorly understood,
cellular response to cisplatin is known to involve activation of MAPK and other signal
transduction pathways. An understanding of early signal transduction events in the response
to cisplatin could be valuable for improving the efficacy of cancer therapy. We compared
cisplatin-induced activation of three MAPKs, JNK, p38, and ERK, in a cisplatin-sensitive …
Although the molecular mechanisms involved in chemoresistance are poorly understood,
cellular response to cisplatin is known to involve activation of MAPK and other signal
transduction pathways. An understanding of early signal transduction events in the response
to cisplatin could be valuable for improving the efficacy of cancer therapy. We compared
cisplatin-induced activation of three MAPKs, JNK, p38, and ERK, in a cisplatin-sensitive …
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