Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal lung disease. A maladaptive
epithelium due to chronic injury is a prominent feature and contributor to pathogenic cellular
communication in IPF. Recent data highlight the concept of a “reprogrammed” lung
epithelium as critical in the development of lung fibrosis. Extracellular vesicles (EVs) are
potent mediators of cellular crosstalk, and recent evidence supports their role in lung
pathologies, such as IPF. Here, we demonstrate that syndecan-1 is overexpressed by the …