Importance Cerebrovascular disease (CVD) and Alzheimer disease are significant causes of
cognitive impairment in the elderly. However, few studies have evaluated the relationship
between CVD and β-amyloid burden in living humans or their synergistic effects on
cognition. Thus, there is a need for better understanding of mild cognitive impairment (MCI)
before clinical deterioration begins. Objective To determine the synergistic effects of β-
amyloid burden and CVD on cognition in patients with subcortical vascular MCI (svMCI) …

IMPORTANCE: Cerebrovascular disease (CVD) and Alzheimer disease are significant
causes of cognitive impairment in the elderly. However, few studies have evaluated the
relationship between CVD and β-amyloid burden in living humans or their synergistic effects
on cognition. Thus, there is a need for better understanding of mild cognitive impairment
(MCI) before clinical deterioration begins. OBJECTIVE: To determine the synergistic effects
of β-amyloid burden and CVD on cognition in patients with subcortical vascular MCI (svMCI) …