Synergistic effects of ischemia and β-amyloid burden on cognitive decline in patients with subcortical vascular mild cognitive impairment

MJ Lee, SW Seo, DL Na, C Kim, JH Park… - JAMA …, 2014 - jamanetwork.com
Importance Cerebrovascular disease (CVD) and Alzheimer disease are significant causes of
cognitive impairment in the elderly. However, few studies have evaluated the relationship
between CVD and β-amyloid burden in living humans or their synergistic effects on
cognition. Thus, there is a need for better understanding of mild cognitive impairment (MCI)
before clinical deterioration begins. Objective To determine the synergistic effects of β-
amyloid burden and CVD on cognition in patients with subcortical vascular MCI (svMCI) …

Synergistic Effects of Ischemia and β-Amyloid Burden on Cognitive Decline in PatientsWith Subcortical Vascular Mild Cognitive Impairment

MJ Lee, SW Seo, DL Na, C Kim, JH Park, GH Kim… - 2014 - ir.ymlib.yonsei.ac.kr
IMPORTANCE: Cerebrovascular disease (CVD) and Alzheimer disease are significant
causes of cognitive impairment in the elderly. However, few studies have evaluated the
relationship between CVD and β-amyloid burden in living humans or their synergistic effects
on cognition. Thus, there is a need for better understanding of mild cognitive impairment
(MCI) before clinical deterioration begins. OBJECTIVE: To determine the synergistic effects
of β-amyloid burden and CVD on cognition in patients with subcortical vascular MCI (svMCI) …
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