Introduction. Sport pharmacology is, first of all, pharmacology of healthy people, its aim is to enhance the body adaptability to the large physical activity [5]. Rational use of drugs (the notion «drugs» in sport pharmacology should be understood as drugs or dietary supplements) during extreme training and competitive loads promotes achievement of individual record-breaking result. Therefore, sport pharmacology studies the impact of drugs in enhanced physical performance, mental stability and ability to quickly restore the athlete body's resources. Competitive athletes are targets for many hardships—strenuous work, injuries, cold and heat, thirst and fatigue, emotional stress. These stresses can lead to immunosuppression and illness. Sports pharmacology has proven useful in helping athletes cope with the physical and emotional stresses of training and competition [8]. Historically sport pharmacology was not acknowledged in the western countries. Instead, the concept of ergogenic aids and sports supplements have been prompted [10]. All in all pharmacological substances, used in sport, include adaptogens, actoprotectors, antioxidants, anabolic substances, substrates of plastic metabolism, bioregulators and energotonics. Succinic acid-one of the strongest antioxidants/antihypoxant of mitochondrial action. It is the intracellular metabolite with low toxicity, has no mutagenic and teratogenic effects. In experimental studies a wide spectrum of pharmacological activity of succinic acid and its derivatives has been shown, in particular cardioprotective, antiischemic, actoprotective, radioprotective, antistress, antydepressant, antioxidant, anticonvulsant activity. Succinic acid preparations are used in sport medicine and treatment of complex diseases such as coronary heart disease, arterial hypertension and bronchial asthma [7]. Antihypoxic activity of succinic acid derivatives is very low and side effect of these substances is increasing of gastric acidity [1, 6]. That is why the aim of this work was to develop, synthesize, describe and predict pharmacological activity of new derivative of malic acid and mono-[(2-dimethyl amino) ethyl ether] of succinic acid. New substance was called antilactate, it must have significant antihypoxic and actoprotective properties and mustn’t influence gastric secretion.

Materials & methods.