Synthesis and antiviral activities of phenanthroindolizidine alkaloids and their derivatives
K Wang, BO Su, Z Wang, M Wu, Z Li, Y Hu… - Journal of agricultural …, 2010 - ACS Publications
Racemic phenanthroindolizidine alkaloids tylophorine, antofine, and deoxytylophorinine,
and optically pure alkaloids S-(+)-tylophorine and R-(−)-tylophorine were synthesized and
evaluated for their antiviral activities against tobacco mosaic virus (TMV). Further salinization
modifications based on tylophorine increased stability and water solubility and improved the
antiviral activity in application. The bioassay results showed that most of these synthesized
compounds showed higher antiviral activity against TMV in vitro and in vivo than commercial …
and optically pure alkaloids S-(+)-tylophorine and R-(−)-tylophorine were synthesized and
evaluated for their antiviral activities against tobacco mosaic virus (TMV). Further salinization
modifications based on tylophorine increased stability and water solubility and improved the
antiviral activity in application. The bioassay results showed that most of these synthesized
compounds showed higher antiviral activity against TMV in vitro and in vivo than commercial …
Synthesis and antiviral activities of phenanthroindolizidine alkaloids and their derivatives.
WKL Wang KaiLiang, SB Su Bo, WZW Wang ZiWen… - 2010 - cabidigitallibrary.org
Racemic phenanthroindolizidine alkaloids tylophorine, antofine, and deoxytylophorinine,
and optically pure alkaloids S-(+)-tylophorine and R-(-)-tylophorine were synthesized and
evaluated for their antiviral activities against tobacco mosaic virus (TMV). Further salinization
modifications based on tylophorine increased stability and water solubility and improved the
antiviral activity in application. The bioassay results showed that most of these synthesized
compounds showed higher antiviral activity against TMV in vitro and in vivo than commercial …
and optically pure alkaloids S-(+)-tylophorine and R-(-)-tylophorine were synthesized and
evaluated for their antiviral activities against tobacco mosaic virus (TMV). Further salinization
modifications based on tylophorine increased stability and water solubility and improved the
antiviral activity in application. The bioassay results showed that most of these synthesized
compounds showed higher antiviral activity against TMV in vitro and in vivo than commercial …
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