Abstract N′-(3, 4-Diarylthiazol-2 (3H)-ylidene)-2-(arylthio) acetohydrazides were
synthesized and evaluated for their antimicrobial activity and cytotoxicity against NIH/3T3
cells. Compound 22 bearing 1-phenyl-1H-tetrazole and p-chlorophenyl moieties was found
to be the most promising antibacterial agent against Pseudomonas aeruginosa, whereas
compound 23 bearing 1-phenyl-1H-tetrazole and p-bromophenyl moieties was the most
promising antifungal agent against Candida albicans. The most effective derivatives were …

Thiazoles belong to the group of azole heterocycles. They are aromatic five-membered
heterocycles containing one sulfur and one nitrogen atom. In recent years thiazoles, their
derivatives, and isomers have gained considerable attention because of their broad
applications in different fields, such as agrochemicals, industrial, and photographic
sensitizers. Also, they have pharmaceutical and biological activities that include
antimicrobial (sulfazole), antiretroviral (ritonavir), antifungal (abafungin), anticancer …