Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly (butyl cyanoacrylate) nanoparticles
J Duan, Y Zhang, S Han, Y Chen, B Li, M Liao… - International journal of …, 2010 - Elsevier
International journal of pharmaceutics, 2010•Elsevier
We have synthesized novel cationic poly (butyl) cyanoacrylate (PBCA) nanoparticles coated
with chitosan, formulation of curcumin nanoparticles. The size and zeta potential of prepared
curcumin nanoparticles were about 200nm and+ 29.11 mV, respectively with 90.04%
encapsulation efficiency. The transmission electron microscopy (TEM) study revealed the
spherical nature of the prepared nanoparticles along with confirmation of particle size.
Curcumin nanoparticles demonstrate comparable in vitro therapeutic efficacy to free …
with chitosan, formulation of curcumin nanoparticles. The size and zeta potential of prepared
curcumin nanoparticles were about 200nm and+ 29.11 mV, respectively with 90.04%
encapsulation efficiency. The transmission electron microscopy (TEM) study revealed the
spherical nature of the prepared nanoparticles along with confirmation of particle size.
Curcumin nanoparticles demonstrate comparable in vitro therapeutic efficacy to free …
We have synthesized novel cationic poly(butyl) cyanoacrylate (PBCA) nanoparticles coated with chitosan, formulation of curcumin nanoparticles. The size and zeta potential of prepared curcumin nanoparticles were about 200nm and +29.11mV, respectively with 90.04% encapsulation efficiency. The transmission electron microscopy (TEM) study revealed the spherical nature of the prepared nanoparticles along with confirmation of particle size. Curcumin nanoparticles demonstrate comparable in vitro therapeutic efficacy to free curcumin against a panel of human hepatocellular cancer cell lines, as assessed by cell viability (3-[4,5-dimethylthiazol-2-yl]2,5-diphenyltetrazolium bromide assay [MTT assay]) and proapoptotic effects (annexin V/propidium iodide staining). In vivo, curcumin nanoparticles suppressed hepatocellular carcinoma growth in murine xenograft models and inhibited tumor angiogenesis. The curcumin nanoparticles’ mechanism of action on hepatocellular cancinoma cells is a mirror that of free curcumin.
Elsevier