New antimycotic drugs are challenging to find, as potential target proteins may have close
human orthologs. We here focus on identifying metabolic targets that are critical for fungal
growth and have minimal similarity to targets among human proteins. We compare and
combine here:(I) direct metabolic network modeling using elementary mode analysis and
flux estimates approximations using expression data,(II) targeting metabolic genes by
transcriptome analysis of condition-specific highly expressed enzymes, and (III) analysis of …