[HTML][HTML] TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
L Caja, F Dituri, S Mancarella… - International journal of …, 2018 - mdpi.com
Transforming growth factor-β (TGF-β) is a cytokine essential for the induction of the fibrotic
response and for the activation of the cancer stroma. Strong evidence suggests that a strong
cross-talk exists among TGF-β and the tissue extracellular matrix components. TGF-β is
stored in the matrix as part of a large latent complex bound to the latent TGF-β binding
protein (LTBP) and matrix binding of latent TGF-β complexes, which is required for an
adequate TGF-β function. Once TGF-β is activated, it regulates extracellular matrix …
response and for the activation of the cancer stroma. Strong evidence suggests that a strong
cross-talk exists among TGF-β and the tissue extracellular matrix components. TGF-β is
stored in the matrix as part of a large latent complex bound to the latent TGF-β binding
protein (LTBP) and matrix binding of latent TGF-β complexes, which is required for an
adequate TGF-β function. Once TGF-β is activated, it regulates extracellular matrix …
TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
L Caja Puigsubirà, F Dituri, S Mancarella… - International Journal of …, 2018 - diposit.ub.edu
Transforming growth factor-β (TGF-β) is a cytokine essential for the induction of the fibrotic
response and for the activation of the cancer stroma. Strong evidence suggests that a strong
cross-talk exists among TGF-β and the tissue extracellular matrix components. TGF-β is
stored in the matrix as part of a large latent complex bound to the latent TGF-β binding
protein (LTBP) and matrix binding of latent TGF-β complexes, which is required for an
adequate TGF-β function. Once TGF-β is activated, it regulates extracellular matrix …
response and for the activation of the cancer stroma. Strong evidence suggests that a strong
cross-talk exists among TGF-β and the tissue extracellular matrix components. TGF-β is
stored in the matrix as part of a large latent complex bound to the latent TGF-β binding
protein (LTBP) and matrix binding of latent TGF-β complexes, which is required for an
adequate TGF-β function. Once TGF-β is activated, it regulates extracellular matrix …
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