TLR-3 stimulation skews M2 macrophages to M1 through IFN-αβ signaling and restricts tumor progression

A Vidyarthi, N Khan, T Agnihotri, S Negi… - Frontiers in …, 2018 - frontiersin.org
… of TLR-3 in the reversion of M2-macrophages to M1. We analyzed the role of TLR-3 stimulation
for skewing M2-macrophages to M1 at mRNA and protein level through qRT-PCR, flow …

Major pathways involved in macrophage polarization in cancer

C Kerneur, CE Cano, D Olive - Frontiers in immunology, 2022 - frontiersin.org
… of M2 macrophages. Moreover, macrophage plasticity is supported by stimuli from the Tumor
… section the main signaling pathways involved in M1-macrophage polarization in humans …

Molecular repolarisation of tumour-associated macrophages

FJ Van Dalen, MHME Van Stevendaal, FL Fennemann… - Molecules, 2018 - mdpi.com
… , M1 polarised macrophages recruit new T h 1 cells via … On the other end of the spectrum
are M2 macrophages. This … of inducing M1 polarisation is through stimulation with TLR …

[HTML][HTML] Intratumoral immunotherapy using a TLR2/3 agonist, L-pampo, induces robust antitumor immune responses and enhances immune checkpoint blockade

WS Lee, DS Kim, JH Kim, Y Heo, H Yang… - … of cancer, 2022 - ncbi.nlm.nih.gov
… Immune responses to stimulation with various TLR agonists were compared. … efficacy by
activating tumor-specific CD8 + T cells and enhancing M1-like macrophages within the tumor

TLR-3 stimulation skews M2 macrophages to M1 through IFN-αβ signaling and restricts tumor progression

D Chatterjee, OR Colegio, MK Tewari, T Agnihotri… - 2018 - dspace.iitrpr.ac.in
… of TLR-3 in the reversion of M2-macrophages to M1. We analyzed the role of TLR-3 stimulation
for skewing M2-macrophages to M1 at mRNA and protein level through qRT-PCR, flow …

Investigating The Possible Effect of Gak-3βinhibitor on Macrophage Transformation Via TLR3 and 4 Signaling Pathway

Y Liu, M Zhou, B Wang, D Huo, M Ha - Proceedings of the 2021 8th …, 2021 - dl.acm.org
macrophage from protumor forming m2 to antitumour M1 and IFN - αβ This paper leads to
the suppression of the tumor … therapeutic role of TLR-3 in the treatment of tumors. INF - αβ …

[HTML][HTML] Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer

C Li, X Xu, S Wei, P Jiang, L Xue… - … immunotherapy of cancer, 2021 - ncbi.nlm.nih.gov
… of M2-like macrophages that were stimulated to transform into … do not transform into the M2
phenotype through the Notch signalingStimulation of TLR-3 polarizes macrophages to an M1

Directing toll-like receptor signaling in macrophages to enhance tumor immunotherapy

Q Zeng, CM Jewell - Current opinion in biotechnology, 2019 - Elsevier
… Generally speaking, M2-like macrophages support tumor … of unique macrophage phenotypes
can be generated by stimulation … to M1-like macrophages in mice, leading to reduced tumor

[HTML][HTML] Targeting innate immune pathways for cancer immunotherapy

LL Cao, JC Kagan - Immunity, 2023 - cell.com
… wherein distinct innate immune signaling pathways activate five key … cold tumors into
inflammatory T cell-enriched “hot” tumors. … in DCs that are needed to stimulate new and long-lived …

Reprogramming the tumor microenvironment with biotechnology

M Kim, NK Lee, CPJ Wang, J Lim, MJ Byun… - Biomaterials …, 2023 - spj.science.org
Tumor cells stimulate major molecular, cellular and physical … -tumor M2 into anti-tumor
M1-like macrophages (Fig. 2b) [39]. … a TLR-3 triggering reverts human M2 to M1. The size of the …