TMAO is associated with mortality: impact of modestly impaired renal function
EG Gruppen, E Garcia, MA Connelly, EJ Jeyarajah… - Scientific reports, 2017 - nature.com
Abstract Trimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared
by the kidney and linked to renal function. We explored the relationship between TMAO and
all-cause mortality, and determined whether this association was modified by renal function.
A prospective study was performed among PREVEND participants to examine associations
of plasma TMAO with all-cause mortality. After median follow-up of 8.3 years in 5,469
participants, 322 subjects died. TMAO was positively associated with age, body mass index …
by the kidney and linked to renal function. We explored the relationship between TMAO and
all-cause mortality, and determined whether this association was modified by renal function.
A prospective study was performed among PREVEND participants to examine associations
of plasma TMAO with all-cause mortality. After median follow-up of 8.3 years in 5,469
participants, 322 subjects died. TMAO was positively associated with age, body mass index …
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