[HTML][HTML] TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells
Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases (IBD)
such as Crohn's disease (CD). Th1-type cytokines—IFN-γ and TNF-α—occupy critical nodes
within these networks and both are associated with disruption of gut epithelial barrier
function. This may be due to their ability to synergistically trigger the death of intestinal
epithelial cells (IECs) via largely unknown mechanisms. In this study, through unbiased
kinome RNAi and drug repurposing screens we identified JAK1/2 kinases as the principal …
such as Crohn's disease (CD). Th1-type cytokines—IFN-γ and TNF-α—occupy critical nodes
within these networks and both are associated with disruption of gut epithelial barrier
function. This may be due to their ability to synergistically trigger the death of intestinal
epithelial cells (IECs) via largely unknown mechanisms. In this study, through unbiased
kinome RNAi and drug repurposing screens we identified JAK1/2 kinases as the principal …
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