TP53-inducible glycolysis and apoptosis regulator (TIGAR) metabolically reprograms carcinoma and stromal cells in breast cancer
YH Ko, M Domingo-Vidal, M Roche, Z Lin… - Journal of biological …, 2016 - ASBMB
A subgroup of breast cancers has several metabolic compartments. The mechanisms by
which metabolic compartmentalization develop in tumors are poorly characterized. TP53
inducible glycolysis and apoptosis regulator (TIGAR) is a bisphosphatase that reduces
glycolysis and is highly expressed in carcinoma cells in the majority of human breast
cancers. Hence we set out to determine the effects of TIGAR expression on breast
carcinoma and fibroblast glycolytic phenotype and tumor growth. The overexpression of this …
which metabolic compartmentalization develop in tumors are poorly characterized. TP53
inducible glycolysis and apoptosis regulator (TIGAR) is a bisphosphatase that reduces
glycolysis and is highly expressed in carcinoma cells in the majority of human breast
cancers. Hence we set out to determine the effects of TIGAR expression on breast
carcinoma and fibroblast glycolytic phenotype and tumor growth. The overexpression of this …
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