Tachykinins (TKs) are a family of peptides which share the common C-terminal sequence
Phe-X-Gly-Leu-MetNH2. In mammals, at least three different TKs, namely substance P (SP), …

… EC 24.11 is present in rat (52) and human lung (53) where it may act to reduce the effects
of tachykinins. l.,ocalization of NEP 24.11 by immunofluorescence technique or in situ …

… likely the primary route of tachykinin metabolism in lung tissue (31). ACE is localized primarily
on endothelial cells where it may mediate intravascular tachykinin catabolism. Its potential …

… allow us to identify the constituents of lung tissue responsible for the SP-induced changes
in lung stiffness and Rti. The increases in Rti and lung elastance can be caused by contraction …

… of tachykinins in tracheal superfused guinea pig lungs. J Clin Invest. 1990:85: 170-176. …
Role of tachykinins in ozoneinduced acute lung injury in guinea pigs. J Appl Physiol. 1993;…

… disappear after lung transplantation [17]. Density of TK innervation in the lungs varies depending
… K, have been detected in extracts from the human lung [21], and in the bronchoalveolar …

… lung tissues 24 h after allergen challenge. Also, increased levels of PPT-A mRNA and increased
numbers of tachykinin … a neuronal source of the increased lung levels of tachykinins [1]. …

… inflam¬ matory actions of tachykinins in the lung. It is of interest that NK2R mRNA is not
altered in the asthmatic lung when compared with the normal lung. Another possible explanation …

… Tachykinins produce their biological effects by stimulating specific tachykinin receptors (NK(1),
NK(2) and NK(3)). Tachykinins have a variety of effects in the lungs. They are among the …

… release of tachykinins. … tachykinins will be released when stimuli are applied via the airway
lumen rather than via the vasculature. In this study we examined the release of tachykinins …