… ble to target both ADCC effector cells and CI‘L with crosslinked … are produced, these too
will be effective in targeting. … Recently, two groups have made heteroantibodies by fusing two …

… -FcyR) (CD16) antibody hetero-cross-linked with anti-target cell antibody. The cytotoxic cell
… + T cell which is targeted by anti-CD3 cross-linked to anti-target cell antibody. Targeted K cell …

… In other experiments, we found that cross-linked heteroantibodies were still required to block
tumor growth when effector cells were preincubated for 3 days with 100 U/ml recombinant …

… T3 crosslinked to an anti-target cell antibody (1 -3). Such crosslinked antibodies bind target
cells … and trigger target cell lysis. Heteroaggregates containing antibodies against the antigen-…

… Some of these exciting explorations include redirecting cytotoxicity to tumor cells, HIV virus,
and infectious agents, targeting enzyme and site-specific activation of anticancer prodrugs …

… (5, 6) or “heteroantibody duplexes” (7) in which two monoclonal … these molecules were
cross-linked intramolecularly by a … anti-T3 cross linked to anti-target cell antibodies. J . Exp. …

… to be specific for tumor [15]. It has been proposed that LAK cells can be targeted to tumor via
… 13] and in vivo in nude mice [25] to target cytotoxic cells to tumor cells, enhancing tumor cell …

… normal donors can be targeted against human ovarian carcinoma … For targeting we used
chemically cross-linked bispecific … and Eisen, HN Heteroantibody duplexes target cells for lysis …

… cross-linked to Fab fragments of rabbit anti-CE by using the agent SPDP. The resulting
heteroantibodies (… of Fab 32.2 X Fab anti-CE heteroantibody at an effector to target ratio of 4:l. B. …

… mechanism in which the cytotoxic cell binds the target cell, forming a bicellular conjugate with
… target cell (Figure 1A). Cytotoxic cells express several types of receptors specific for target …