[HTML][HTML] Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer's disease patients: application of a second-generation encapsulated …
Background Targeted delivery of nerve growth factor (NGF) has emerged as a potential
therapy for Alzheimer's disease (AD) due to its regenerative effects on basal forebrain
cholinergic neurons. This hypothesis has been tested in patients with AD using
encapsulated cell biodelivery of NGF (NGF-ECB) in a first-in-human study. We report our
results from a third-dose cohort of patients receiving second-generation NGF-ECB implants
with improved NGF secretion. Methods Four patients with mild to moderate AD were …
therapy for Alzheimer's disease (AD) due to its regenerative effects on basal forebrain
cholinergic neurons. This hypothesis has been tested in patients with AD using
encapsulated cell biodelivery of NGF (NGF-ECB) in a first-in-human study. We report our
results from a third-dose cohort of patients receiving second-generation NGF-ECB implants
with improved NGF secretion. Methods Four patients with mild to moderate AD were …
[引用][C] Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer's disease patients: application of a second‑generation encap‑sulated cell …
H Eyjolfsdottir, M Eriksdotter, B Linderoth, G Lind… - … doi. org/10.1186/s13195-016-0195 …
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