Targeted regulation of imprinted genes by synthetic zinc-finger transcription factors
Epigenetic control of transcription is essential for mammalian development and its
deregulation causes human disease. For example, loss of proper imprinting control at the
IGF2–H19 domain is a hallmark of cancer and Beckwith–Wiedemann syndrome, with no
targeted therapeutic approaches available. To address this deficiency, we engineered zinc-
finger transcription proteins (ZFPs) that specifically activate or repress the IGF2 and H19
genes in a domain-dependent manner. Importantly, we used these ZFPs successfully to …
deregulation causes human disease. For example, loss of proper imprinting control at the
IGF2–H19 domain is a hallmark of cancer and Beckwith–Wiedemann syndrome, with no
targeted therapeutic approaches available. To address this deficiency, we engineered zinc-
finger transcription proteins (ZFPs) that specifically activate or repress the IGF2 and H19
genes in a domain-dependent manner. Importantly, we used these ZFPs successfully to …
Targeted regulation of imprinted genes by synthetic zinc-finger transcription factors
PQ Liu, V Ginjala, R Ohlsson, M Oshimura… - Gene Therapy, 2003 - cir.nii.ac.jp
Epigenetic control of transcription is essential for mammalian development and its
deregulation causes human disease. For example, loss of proper imprinting control at the
IGF2-H19 domain is a hallmark of cancer and Beckwith-Wiedemann syndrome, with no
targeted therapeutic approaches available. To address this deficiency, we engineered zinc-
finger transcription proteins (ZFPs) that specifically activate or repress the IGF2 and H19
genes in a domain-dependent manner. Importantly, we used these ZFPs successfully to …
deregulation causes human disease. For example, loss of proper imprinting control at the
IGF2-H19 domain is a hallmark of cancer and Beckwith-Wiedemann syndrome, with no
targeted therapeutic approaches available. To address this deficiency, we engineered zinc-
finger transcription proteins (ZFPs) that specifically activate or repress the IGF2 and H19
genes in a domain-dependent manner. Importantly, we used these ZFPs successfully to …
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