Specific targeted therapy of chronic myelogenous leukemia with imatinib
MWN Deininger, BJ Druker - Pharmacological reviews, 2003 - ASPET
Chronic myeloid leukemia (CML) is characterized by the Philadelphia translocation that fuses
BCR sequences from chromosome 22 upstream of the ABL gene on chromosome 9. The …
BCR sequences from chromosome 22 upstream of the ABL gene on chromosome 9. The …
Resistance to targeted therapy in chronic myelogenous leukemia
A Hochhaus, P Erben, T Ernst, MC Mueller - Seminars in hematology, 2007 - Elsevier
The advent of the Bcr-Abl selective tyrosine kinase inhibitor imatinib mesylate (Glivec,
Gleevec, Novartis, East Hanover, NJ) has substantially changed the treatment landscape for …
Gleevec, Novartis, East Hanover, NJ) has substantially changed the treatment landscape for …
Targeted therapy in chronic myeloid leukemia
… targeted therapies that block Bcr–Abl tyrosine kinase activity. Imatinib, the current first-line
therapy for … This review will discuss the use of targeted therapies in CML, particularly in the …
therapy for … This review will discuss the use of targeted therapies in CML, particularly in the …
Targeted therapy of chronic myeloid leukemia
C Sullivan, C Peng, Y Chen, D Li, S Li - Biochemical pharmacology, 2010 - Elsevier
… of targeting a key … targeted therapies of CML using BCR-ABL kinase inhibitors, with a
focus on the importance of developing a targeted therapy of CML through identification of target …
focus on the importance of developing a targeted therapy of CML through identification of target …
Success story of targeted therapy in chronic myeloid leukemia: a population-based study of patients diagnosed in Sweden from 1973 to 2008
M Björkholm, L Ohm, S Eloranta, Å Derolf… - Journal of Clinical …, 2011 - ascopubs.org
… Chronic myeloid leukemia (CML) management changed dramatically with the
development of imatinib mesylate (IM), the first tyrosine kinase inhibitor targeting the BCR-ABL1 …
development of imatinib mesylate (IM), the first tyrosine kinase inhibitor targeting the BCR-ABL1 …
Advances in targeted therapy for chronic myeloid leukemia
KWL Yee, A Keating - Expert Review of Anticancer Therapy, 2003 - Taylor & Francis
… chronic myeloid leukemia and the potential therapeutic impact of small molecule inhibitors
that target … growth or survival of the leukemic cells in patients with chronic myeloid leukemia. …
that target … growth or survival of the leukemic cells in patients with chronic myeloid leukemia. …
Pushing the limits of targeted therapy in chronic myeloid leukaemia
T O'hare, MS Zabriskie, AM Eiring… - Nature Reviews …, 2012 - nature.com
… BCR-ABL1 is the central therapeutic target in CML and the … into a paradigm for molecularly
targeted therapy. A wealth of … of targeted therapy for CML from a biological perspective. …
targeted therapy. A wealth of … of targeted therapy for CML from a biological perspective. …
Targeted chronic myeloid leukemia therapy: seeking a cure
C Fausel - American journal of health-system pharmacy, 2007 - academic.oup.com
… The development of therapeutic agents targeting BCR-ABL has revolutionized the treatment
of chronic myeloid leukemia (CML). Imatinib has successfully allowed CML patients to re…
of chronic myeloid leukemia (CML). Imatinib has successfully allowed CML patients to re…
Mechanisms of resistance to targeted therapies in chronic myeloid leukemia
F Lussana, T Intermesoli, P Stefanoni… - … in cancer therapy, 2018 - Springer
Patients with newly diagnosed chronic myeloid leukemia (CML) usually received as first-line
treatment a first- or second-generation tyrosine kinase inhibitor (TKI). Although initial …
treatment a first- or second-generation tyrosine kinase inhibitor (TKI). Although initial …
Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring
E Jabbour, H Kantarjian - American journal of hematology, 2020 - Wiley Online Library
… Chronic myeloid leukemia (… Chronic myeloid leukemia may be more difficult to differentiate
from other myeloproliferative or myelodysplastic syndromes. Patients with agnogenic myeloid …
from other myeloproliferative or myelodysplastic syndromes. Patients with agnogenic myeloid …
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