Targeting Nrf2/Keap1 signaling pathway by bioactive natural agents: Possible therapeutic strategy to combat liver disease
Background Nuclear factor erythroid 2-related factor (Nrf2), a stress-activated transcription
factor, has been documented to induce a defense mechanism against oxidative stress
damage, and growing evidence considers this signaling pathway a key pharmacological
target for the treatment of liver diseases. Purpose The present review highlights the role of
phytochemical compounds in activating Nrf2 and mitigate toxicant-induced stress on liver
injury. Methods A comprehensive search of published articles was carried out to focus on …
factor, has been documented to induce a defense mechanism against oxidative stress
damage, and growing evidence considers this signaling pathway a key pharmacological
target for the treatment of liver diseases. Purpose The present review highlights the role of
phytochemical compounds in activating Nrf2 and mitigate toxicant-induced stress on liver
injury. Methods A comprehensive search of published articles was carried out to focus on …
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