Tempol improves neuroinflammation and delays motor dysfunction in a mouse model (SOD1G93A) of ALS
Background The development of new therapeutic strategies to treat amyotrophic lateral
sclerosis (ALS) is of utmost importance. The use of cyclic nitroxides such as tempol may
provide neuroprotection and improve lifespan. We investigated whether tempol (50 mg/kg)
presents therapeutic potential in SOD1 G93A transgenic mice. Methods Tempol treatment
began at the asymptomatic phase of the disease (10th week) and was administered every
other day until week 14, after which it was administered twice a week until the final stage of …
sclerosis (ALS) is of utmost importance. The use of cyclic nitroxides such as tempol may
provide neuroprotection and improve lifespan. We investigated whether tempol (50 mg/kg)
presents therapeutic potential in SOD1 G93A transgenic mice. Methods Tempol treatment
began at the asymptomatic phase of the disease (10th week) and was administered every
other day until week 14, after which it was administered twice a week until the final stage of …
Tempol improves neuroinflammation and delays motor dysfunction in a mouse model (SOD1G93A) of ALS
ALR Oliveira - 2019 - lareferencia.info
The development of new therapeutic strategies to treat amyotrophic lateral sclerosis (ALS) is
of utmost importance. The use of cyclic nitroxides such as tempol may provide
neuroprotection and improve lifespan. We investigated whether tempol (50? mg/kg)
presents therapeutic potential in SOD1...
of utmost importance. The use of cyclic nitroxides such as tempol may provide
neuroprotection and improve lifespan. We investigated whether tempol (50? mg/kg)
presents therapeutic potential in SOD1...
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