[HTML][HTML] Ten years of pathway analysis: current approaches and outstanding challenges
Pathway analysis has become the first choice for gaining insight into the underlying biology
of differentially expressed genes and proteins, as it reduces complexity and has increased
explanatory power. We discuss the evolution of knowledge base–driven pathway analysis
over its first decade, distinctly divided into three generations. We also discuss the limitations
that are specific to each generation, and how they are addressed by successive generations
of methods. We identify a number of annotation challenges that must be addressed to …
of differentially expressed genes and proteins, as it reduces complexity and has increased
explanatory power. We discuss the evolution of knowledge base–driven pathway analysis
over its first decade, distinctly divided into three generations. We also discuss the limitations
that are specific to each generation, and how they are addressed by successive generations
of methods. We identify a number of annotation challenges that must be addressed to …
Pathway analysis has become the first choice for gaining insight into the underlying biology of differentially expressed genes and proteins, as it reduces complexity and has increased explanatory power. We discuss the evolution of knowledge base–driven pathway analysis over its first decade, distinctly divided into three generations. We also discuss the limitations that are specific to each generation, and how they are addressed by successive generations of methods. We identify a number of annotation challenges that must be addressed to enable development of the next generation of pathway analysis methods. Furthermore, we identify a number of methodological challenges that the next generation of methods must tackle to take advantage of the technological advances in genomics and proteomics in order to improve specificity, sensitivity, and relevance of pathway analysis.
![](/scholar/images/qa_favicons/plos.org.png)
以上显示的是最相近的搜索结果。 查看全部搜索结果