The “stop” and “go” of nicotine dependence: role of GABA and glutamate
MS D'Souza, A Markou - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
Nicotine plays an important role in the initiation and maintenance of tobacco smoking.
Importantly, chronic nicotine exposure alters the function of brain reward systems, resulting
in the development of a nicotine-dependent state. This nicotine-dependent state is
associated with aversive affective and somatic signs upon abstinence from smoking, often
leading to relapse in abstinent smokers. This article reviews the role of the major excitatory
and inhibitory neurotransmitters glutamate and γ-aminobutyric acid (GABA), respectively, in …
Importantly, chronic nicotine exposure alters the function of brain reward systems, resulting
in the development of a nicotine-dependent state. This nicotine-dependent state is
associated with aversive affective and somatic signs upon abstinence from smoking, often
leading to relapse in abstinent smokers. This article reviews the role of the major excitatory
and inhibitory neurotransmitters glutamate and γ-aminobutyric acid (GABA), respectively, in …
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