The ATP binding cassette multidrug transporter LmrA and lipid transporter MsbA have overlapping substrate specificities
G Reuter, T Janvilisri, H Venter, S Shahi… - Journal of Biological …, 2003 - ASBMB
LmrA is an ATP binding cassette (ABC) multidrug transporter in Lactococcus lactis that is a
structural and functional homologue of the human multidrug resistance P-glycoprotein
MDR1 (ABCB1). LmrA is also homologous to MsbA, an essential ABC transporter in
Escherichia coli involved in the trafficking of lipids, including Lipid A. We have compared the
substrate specificities of LmrA and MsbA in detail. Surprisingly, LmrA was able to
functionally substitute for a temperature-sensitive mutant MsbA in E. coli WD2 at non …
structural and functional homologue of the human multidrug resistance P-glycoprotein
MDR1 (ABCB1). LmrA is also homologous to MsbA, an essential ABC transporter in
Escherichia coli involved in the trafficking of lipids, including Lipid A. We have compared the
substrate specificities of LmrA and MsbA in detail. Surprisingly, LmrA was able to
functionally substitute for a temperature-sensitive mutant MsbA in E. coli WD2 at non …
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