Tangerang City is a city with a high population, vehicles, and industries, so the pollutant emissions in the air are increasing. It has a high contribution in the occurrence of ARI (Acute Respiratory Infection). These pollutants are PM 10, CO, SO 2, NO 2, and O 3. In addition, meteorological factors such as air temperature, relative humidity, rainfall, wind velocity, and the length of sun exposure also affect the occurrence of the disease. Research Purposes: The purpose of this research is to find out how the correlation between meteorological factors and ambient air quality with the incidence of ARI in Tangerang City during 2010 to 2019. Research Methodology: This research uses analytic observational research, quantitative approaches, and retrospective cohort study design, also ecological study. The population used as a sample is all the data of meteorological factors, ambient air quality, and the incidence of ARI in Tangerang City during 2010 to 2019. Correlation analysis was performed using regression correlation analysis, simple linear regression test, and multiple linear regression test. Research Result: The result showed that meteorological factors and ambient air quality associated with the incidence of ARI are relative humidity (p= 0,039), rainfall (p= 0,044), wind velocity (p= 0,033), the length of sun exposure (p= 0,042), PM 10 (p= 0,024), CO (p= 0,040), NO 2 (p= 0,049), and O 3 (p= 0,039).