The Arabidopsis Hop1 homolog ASY1 mediates cross-over assurance and interference

G Pochon, IM Henry, C Yang, N Lory… - PNAS …, 2023 - academic.oup.com
The chromosome axis plays a crucial role in meiotic recombination. Here, we study the
function of ASY1, the Arabidopsis homolog of the yeast chromosome axis-associated
component Hop1. Specifically, we characterized cross-over (CO) distribution in female and
male meiosis by deep sequencing of the progeny of an allelic series of asy1 mutants.
Combining data from nearly 1,000 individual plants, we find that reduced ASY1 functionality
leads to genomic instability and sometimes drastic genomic rearrangements. We further …

The Arabidopsis Hop1 homolog ASY1 mediates cross-over assurance and interference

N Fernández Jiménez, M Pradillo Orellana, G Pochon… - 2022 - docta.ucm.es
The chromosome axis plays a crucial role in meiotic recombination. Here, we study the
function of ASY1, the Arabidopsis homolog of the yeast chromosome axis-associated
component Hop1. Specifically, we characterized cross-over (CO) distribution in female and
male meiosis by deep sequencing of the progeny of an allelic series of asy1 mutants.
Combining data from nearly 1,000 individual plants, we find that reduced ASY1 functionality
leads to genomic instability and sometimes drastic genomic rearrangements. We further …
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