The DNMT3 family of mammalian de novo DNA methyltransferases
F Chédin - Progress in molecular biology and translational …, 2011 - Elsevier
The deposition of DNA methylation at promoters of transposons, X-linked genes, imprinted
genes, and other lineage-specific genes is clearly associated with long-term transcriptional
silencing. Thus, DNA methylation represents a key layer of epigenetic information in
mammals that is required for embryonic development, germline differentiation, and, as
shown more recently, for the function and maturation of neuronal tissues. The DNMT3A,
DNMT3B, and DNMT3L proteins are primarily responsible for the establishment of genomic …
genes, and other lineage-specific genes is clearly associated with long-term transcriptional
silencing. Thus, DNA methylation represents a key layer of epigenetic information in
mammals that is required for embryonic development, germline differentiation, and, as
shown more recently, for the function and maturation of neuronal tissues. The DNMT3A,
DNMT3B, and DNMT3L proteins are primarily responsible for the establishment of genomic …
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