The HVCN1 voltage‐gated proton channel contributes to pH regulation in canine ventricular myocytes
J Ma, X Gao, Y Li, TE DeCoursey… - The Journal of …, 2022 - Wiley Online Library
Regulation of intracellular pH (pHi) in cardiomyocytes is crucial for cardiac function;
however, currently known mechanisms for direct or indirect extrusion of acid from
cardiomyocytes seem insufficient for energetically efficient extrusion of the massive H+ loads
generated under in vivo conditions. In cardiomyocytes, voltage‐sensitive H+ channel activity
mediated by the HVCN1 proton channel would be a highly efficient means of disposing of
H+, while avoiding Na+ loading, as occurs during direct acid extrusion via Na+/H+ exchange …
however, currently known mechanisms for direct or indirect extrusion of acid from
cardiomyocytes seem insufficient for energetically efficient extrusion of the massive H+ loads
generated under in vivo conditions. In cardiomyocytes, voltage‐sensitive H+ channel activity
mediated by the HVCN1 proton channel would be a highly efficient means of disposing of
H+, while avoiding Na+ loading, as occurs during direct acid extrusion via Na+/H+ exchange …
The HVCN1 Voltage-Gated Proton Channel Contributes to Ph Regulation in Canine Ventricular Myocytes
J Ma, X Gao, Y Li, T DeCoursey, GE Shull, H Wang - Circulation, 2021 - Am Heart Assoc
Regulation of intracellular pH (pHi) in cardiomyocytes is crucial for cardiac function;
however, currently known mechanisms for direct or indirect extrusion of acid from
cardiomyocytes seem insufficient for energetically-efficient extrusion of the massive H+
loads generated under in vivo conditions. In cardiomyocytes, voltage-sensitive H+ channel
activity mediated by the HVCN1 proton channel would be a highly efficient means of
disposing of H+, while avoiding Na+-loading, as occurs during direct acid extrusion via …
however, currently known mechanisms for direct or indirect extrusion of acid from
cardiomyocytes seem insufficient for energetically-efficient extrusion of the massive H+
loads generated under in vivo conditions. In cardiomyocytes, voltage-sensitive H+ channel
activity mediated by the HVCN1 proton channel would be a highly efficient means of
disposing of H+, while avoiding Na+-loading, as occurs during direct acid extrusion via …
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