The IL-4Rα Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice
B Yang, H Wilkie, M Das, M Timilshina… - Journal of Allergy and …, 2023 - Elsevier
Background Atopic dermatitis (AD) is characterized by TH 2-dominated skin inflammation
and systemic response to cutaneously encountered antigens. The TH 2 cytokines IL-4 and IL-
13 play a critical role in the pathogenesis of AD. The Q576-> R576 polymorphism in the IL-4
receptor alpha (IL-4Rα) chain common to IL-4 and IL-13 receptors alters IL-4 signaling and
is associated with asthma severity. Objective We sought to investigate whether the IL-4Rα
R576 polymorphism is associated with AD severity and exaggerates allergic skin …
and systemic response to cutaneously encountered antigens. The TH 2 cytokines IL-4 and IL-
13 play a critical role in the pathogenesis of AD. The Q576-> R576 polymorphism in the IL-4
receptor alpha (IL-4Rα) chain common to IL-4 and IL-13 receptors alters IL-4 signaling and
is associated with asthma severity. Objective We sought to investigate whether the IL-4Rα
R576 polymorphism is associated with AD severity and exaggerates allergic skin …
以上显示的是最相近的搜索结果。 查看全部搜索结果