Mycobacterium tuberculosis is the causative agent of tuberculosis, which is becoming an
increasingly global public health problem due to the rise of drug-resistant strains. While
residing in the human host, M. tuberculosis needs to acquire iron for its survival. M.
tuberculosis has two iron uptake mechanisms, one that utilizes non-heme iron and another
that taps into the vast host heme-iron pool. To date, proteins known to be involved in
mycobacterial heme uptake are Rv0203, MmpL3, and MmpL11. Whereas Rv0203 transports …