[HTML][HTML] The N6-methyladenosine writer WTAP contributes to the induction of immune tolerance post kidney transplantation by targeting regulatory T cells
Z Wang, Y Qi, Y Feng, H Xu, J Wang, L Zhang… - Laboratory …, 2022 - Elsevier
Abstract N6-methyladenosine (m6A) modification is involved in diverse immunoregulation,
while the relationship between m6A modification and immune tolerance post kidney
transplantation remains unclear. Expression of Wilms tumor 1-associating protein (WTAP),
an m6A writer, was firstly detected in tolerant kidney transplant recipients (TOL). Then the
role of WTAP on regulatory T (Treg) cell differentiation and function in CD4+ T cells from
kidney transplant recipients with immune rejection (IR) was investigated. The potential target …
while the relationship between m6A modification and immune tolerance post kidney
transplantation remains unclear. Expression of Wilms tumor 1-associating protein (WTAP),
an m6A writer, was firstly detected in tolerant kidney transplant recipients (TOL). Then the
role of WTAP on regulatory T (Treg) cell differentiation and function in CD4+ T cells from
kidney transplant recipients with immune rejection (IR) was investigated. The potential target …
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