The NLRP3 inflammasome: Mechanism of action, role in disease and therapies
L Wang, AV Hauenstein - Molecular aspects of medicine, 2020 - Elsevier
NLRP3 is the best characterized cytosolic nod-like pattern recognition receptor which can
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to
the formation of a cytosolic multiprotein signaling complex called the inflammasome, which
serves as a platform for caspase-1 activation leading to the processing of proinflammatory
cytokines IL-1β, IL-18 and GSDMD mediated cell death. This form of pyroptotic cell death
represents a major pathway of inflammation. Growing evidence has indicated …
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to
the formation of a cytosolic multiprotein signaling complex called the inflammasome, which
serves as a platform for caspase-1 activation leading to the processing of proinflammatory
cytokines IL-1β, IL-18 and GSDMD mediated cell death. This form of pyroptotic cell death
represents a major pathway of inflammation. Growing evidence has indicated …
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