BRG1 and BRM are ATPase core subunits of the human SWI/SNF chromatin remodelling
complexes mainly associated with transcriptional initiation. They also have a role in
alternative splicing, which has been shown for BRM-containing SWI/SNF complexes at a few
genes. Here, we have identified a subset of genes which harbour alternative exons that are
affected by SWI/SNF ATPases by expressing the ATPases BRG1 and BRM in C33A cells, a
BRG1-and BRM-deficient cell line, and analysed the effect on splicing by RNA sequencing …

BRG1 and BRM are ATPase core subunits of the human SWI/SNF chromatin remodelling
complexes. The function of the SWI/SNF complexes in transcriptional initiation has been well
studied, while a function in alternative splicing has only been studied for a few cases for
BRM-containing SWI/SNF complexes. Here, we have expressed BRG1 in C33A cells, a
BRG1 and BRM-deficient cell line, and we have analysed the effects on the transcriptome by
RNA sequencing. We have shown that BRG1 expression affects the splicing of a subset of …